Mecobalamin as A Neuroprotective Effector Against Oxaliplatin-Based Chemotherapy in Colon and Rectal Cancer Patients- Crimson Publishers
Mecobalamin as A Neuroprotective Effector Against Oxaliplatin-Based Chemotherapy in Colon and Rectal Cancer Patients- Crimson Publishers Palliative chemotherapy prolongs survival and improves quality of life. However, a variety of chemotherapeutics including oxaliplatin can cause severe side effects during treatments, leading to painful symptoms that might result in the interruption of cancer treatment. Although adding oxaliplatin to fluorouracil and leucovorin in adjuvant chemotherapy for colon and rectal cancer may improve disease-free survival, it also increases grade 3-4 sensory neuropathy. Our study aimed to determine whether oral Mecobalamin is neuroprotective against oxaliplatin-induced neuropathy. Forty-six stage III colon and rectal cancer patients receiving adjuvant biweekly oxaliplatin were randomized to oral Mecobalamin (1,500mg; case group) or placebo (control group). Clinical neurological and electrophysiological evaluations were performed at baseline and after 4, 8, an...