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Research Progress of Matrix Metalloproteinases Deriving from Parasites- Crimson Publishers

Research Progress of Matrix Metalloproteinases Deriving from Parasites- Crimson Publishers



Matrix metalloproteinases (MMPs) is a large family. It is named because it needs metal ions like Ca2+, Zn2+as cofactors. Its family members have similar structures and are generally composed of five domains with different functions:

A. The hydrophobic signal peptide sequences;

B. The prepeptide region, mainly used to maintain the stability of the zymogen. When the region is cut off by exogenous enzymes, MMPs zymogen is activated.

C. The catalytic active region, having zinc ion binding sites, crucial for the enzyme catalysis.

D. The hinge region rich in proline.

E. The carboxyl terminal region, related to the substrate specificity of the enzyme [1].

https://crimsonpublishers.com/rmes/fulltext/RMES.000730.php

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