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The Malachite Wen-Myeloid Sarcoma- Crimson Publishers

The Malachite Wen-Myeloid Sarcoma- Crimson Publishers

 


Contingent to World Health Organization (WHO) classification, myeloid sarcoma is denominated as a tumefaction comprised of myeloblasts amalgamated at an anatomical site divergent from the bone marrow which engenders distortion of normal tissue architecture. Generally, myeloid sarcoma is contemplated to be equivalent to and concurrent with acute myeloid leukaemia (AML), although lesions may occur in isolation. Additionally designated as granulocytic sarcoma, chloroma or extramedullary myeloid tumour, myeloid sarcoma categorically represents as a distinct tumefaction associated with architectural effacement of circumscribing soft tissue. Myeloid sarcoma may emerge as a de novo lesion or manifest as therapy related myeloid neoplasm or as disease progression within myeloproliferative neoplasm (MPN), myelodysplastic syndrome (MDS) or myelodysplastic / myeloproliferative neoplasm (MDS / MPN). In contrast, leukaemia cutis (LC) is a nonspecific terminology adopted to describe cutaneous infiltration of neoplastic leukocytes which configure as mature or immature myeloid or lymphoid cellular components. Nevertheless, as per WHO classification criterion, leukaemia cutis remains nonequivalent to myeloid sarcoma [1,2]. Leukaemia cutis may emerge in subjects delineating non acute myeloid leukaemia (non-AML), Myeloproliferative Neoplasm (MPN), Myelodysplastic Syndrome (MDS) or Myelodysplastic/ Myeloproliferative neoplasm (MDS / MPN) as Chronic Myelomonocytic Leukemia (CMML).

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