Free Amino Acid and Their Derivatives: Plastic Substrates, Specific Regulators of Metabolism and Markers | Crimson Publishers
Free Amino Acid and Their Derivatives: Plastic Substrates,Specific Regulators of Metabolism and Markers by Nefyodov L in Journal of Medical Sciences & Health
On the basis of the experimental
data we suggest that the differences discovered in certain amino acids
concentrations in blood plasma, red blood cells and tumors are criteria in
early diagnostics of primary cancerous growth as well as in estimation of the
efficacy of specific cancer treatment. Clinical studies on biological fluids
and tumors of 1,495 patients with cancer of the mammary gland, lungs, prostate,
ovaries, bladder or digestive tract showed significant changes in physiological
concentrations of amino acids which either directly or indirectly regulate
processes of antitumor response, oncogenesis, immunogenesis and apoptosis were
shown. Our strategy of application of amino acids as medicinal preparations
includes a targeted effect on the functional and metabolic relationships which
are changed in specific pathology through the effect on the regulatory
mechanisms of intermediate metabolic reactions, limiting stages of metabolic
flows, utilization of energy substrates and transport systems restricting the
processes of amino acids pool formation. The creation methodology of
pathogenetic compositions of amino acids and their derivatives on the basis of
their physiological concentration for practical application of their regulatory
effects in oncology was discussed.
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