Polymicrobial Injection-Site Abscesses Associated with Contaminated Methylprednisolone Injections in Florida_Crimson Publishers
Polymicrobial Injection-Site Abscesses Associated with Contaminated Methylprednisolone Injections in Florida by James Matthias in Research in Medical & Engineering Sciences
https://crimsonpublishers.com/rmes/fulltext/RMES.000529.php
Intramuscular injections have been identified as the cause of
many infectious disease outbreaks in the United States. Identified
sources include intrinsically contaminated product or a breakdown
in infection control practices leading to extrinsic contamination
of the product [1-5] In September 2012, a national outbreak
investigation involving the New England Compounding Center
(NECC), identified at least 61 deaths and 749 adverse events from
intrinsically contaminated preservative-free Methylprednisolone
acetate (pf-MPA) primarily injected through epidural or intraspinal
sites [6-9]. In addition to the NECC outbreak as of 2012,
11 outbreaks are known to have occurred since January 2000 in
which compounded products have resulted in an additional 207
infections and 17 deaths [10]. On May 28, 2013, the Main Street
Family Pharmacy (MSFP) of Tennessee recalled all lots of sterile
compounded products manufactured since December 1, 2012 [11].
On June 7, 2013, the Food and Drug Administration (FDA) reported
that it had identified bacterial and fungal growth from two separate
lots of unopened 80mg/ml, 10mL vials of pf-MPA from MSFP; lot
011413dan and lot 010913dan [12]. In total, 96 facilities in 17
states received sterile compounded products from MSFP, including
pf-MPA [12]. Three of these facilities were located in Florida;
however, only one of the Florida facilities received the recalled
pf-MPA (80mg/ml, 10mL vials) and reported potential adverse
events among injected patients. As of June 27, 2013, the Centers for
Disease Control and Prevention
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