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Polymicrobial Injection-Site Abscesses Associated with Contaminated Methylprednisolone Injections in Florida_Crimson Publishers

Polymicrobial Injection-Site Abscesses Associated with Contaminated Methylprednisolone Injections in Florida by James Matthias in Research in Medical & Engineering Sciences

https://crimsonpublishers.com/rmes/fulltext/RMES.000529.php

Intramuscular injections have been identified as the cause of many infectious disease outbreaks in the United States. Identified sources include intrinsically contaminated product or a breakdown in infection control practices leading to extrinsic contamination of the product [1-5] In September 2012, a national outbreak investigation involving the New England Compounding Center (NECC), identified at least 61 deaths and 749 adverse events from intrinsically contaminated preservative-free Methylprednisolone acetate (pf-MPA) primarily injected through epidural or intraspinal sites [6-9]. In addition to the NECC outbreak as of 2012, 11 outbreaks are known to have occurred since January 2000 in which compounded products have resulted in an additional 207 infections and 17 deaths [10]. On May 28, 2013, the Main Street Family Pharmacy (MSFP) of Tennessee recalled all lots of sterile compounded products manufactured since December 1, 2012 [11]. On June 7, 2013, the Food and Drug Administration (FDA) reported that it had identified bacterial and fungal growth from two separate lots of unopened 80mg/ml, 10mL vials of pf-MPA from MSFP; lot 011413dan and lot 010913dan [12]. In total, 96 facilities in 17 states received sterile compounded products from MSFP, including pf-MPA [12]. Three of these facilities were located in Florida; however, only one of the Florida facilities received the recalled pf-MPA (80mg/ml, 10mL vials) and reported potential adverse events among injected patients. As of June 27, 2013, the Centers for Disease Control and Prevention

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