Dynamic Freedom: Substrate Stress Relaxation Stimulates Cell Responses by Kamol Dey in Research in Medical & Engineering Sciences
Natural tissues comprise a population of
cells, extra cellular matrix (ECM) and signaling biomolecules. The only living
component, cell, interacts with each other and with the ECM in an incredibly
multifaceted way. From the materials point of view, cells are highly dynamic
viscoelastic materials; reside in highly dynamic three dimensional (3D)
viscoelastic ECM, communicate with its surrounding in a highly dynamic and
complex way, and form a highly dynamic viscoelastic tissue [1,2]. The cells can
continually read the microenviromental cues such as stiffness, porosity,
topography etc. and respond to them in a mechano-sensitive way to maintain the
both cellular and tissue health [3]. It has been long recognized that matrix
integrity or stiffness has profound influences on cell function and fate [4-7].
Furthermore, cells exert forces on the matrix and gauge the feedback to make cell-fate
decisions [8]. In a recent study, Chaudhuri et al. [9] show that stress
relaxation, the ability of the matrix to dissipate cell-exerted forces, is a
key mechanical signal to modulate stem cells fate and activity [9].
For more open access journals in crimsonpublishers Please click on link: https://crimsonpublishers.com
For more articles on Research in Medical & Engineering Sciences Please click on link:
Comments
Post a Comment