Correction of Metabolic Imbalance and Formation of Amino Acid Pool in Cardiovascular Pathology- Crimson Publishers

A review of data on the mechanisms of formation of the pool of free amino acids in cardiovascular insufficiency and methods for correcting of metabolic imbalance. The relevance of studies on the role of amino acids in the pathogenesis, prevention and treatment of Cardiovascular Insufficiency (CVI) is primarily due to the significant practical results of the use of highly purified substances of this class of compounds and their compositions in the treatment of cardiovascular pathology [1-7]. At the same time, the most significant number of applied research is devoted to the search for marker amino acids or their derivatives for the diagnosis of heart and vascular diseases [8-12]. It has been convincingly demonstrated that elimination or correction of changes in intermediate metabolism can be achieved by using individual amino acids and their derivatives, or by combining them as universal natural bioregulators - compounds that directly affect the mechanisms of myocardial cell metabolism in physiological concentrations To date, there is evidence of the importance of amino acids not only as building blocks for protein synthesis, but also regulators of gene expression at the level of mRNA translation by the mTOR-dependent mechanism, signaling molecules and modifiers of biological responses, as well as precursors of a wide range of bioregulators that play a key role in integration of the main metabolic flows in vascular pathology [2-4,11,13,14]. The human heart uses a large amount of free amino acids as regulators of both myocardial protein metabolism and as substrates for energy metabolism.

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