Escherichia coli Harboring Mcr-1 on a Novel Plasmid in a Mink in Eastern China- Crimson Publishers
In
the current study, we described the characterization of an mcr-1-positive E.
coli isolate from a dead mink in Dongping Lake, China. The molecular
characterization of plasmids was also investigated. The strain was resistant to
colistin, but it remained susceptible to several other agents, including
amikacin, piperacillin-tazobactam, all carbapenems, and ESBLs. E. coli Mink_1
belonged to sequence type 140. Whole Genome Sequencing (WGS) showed that two
plasmids, pM1mcr and pM1ctx, coexisted in the same bacterial. Blast and
phylogenetic tree imply that Epidemic plasmids are vehicles for the
dissemination of colistin resistance genes among the Enterobacterales.
Restrictive use of antibiotics in animal husbandry should be taken to reduce
the dissemination of mcr-1.
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