The Malachite Wen-Myeloid Sarcoma- Crimson Publishers Contingent to World Health Organization (WHO) classification, myeloid sarcoma is denominated as a tumefaction comprised of myeloblasts amalgamated at an anatomical site divergent from the bone marrow which engenders distortion of normal tissue architecture. Generally, myeloid sarcoma is contemplated to be equivalent to and concurrent with acute myeloid leukaemia (AML), although lesions may occur in isolation. Additionally designated as granulocytic sarcoma, chloroma or extramedullary myeloid tumour, myeloid sarcoma categorically represents as a distinct tumefaction associated with architectural effacement of circumscribing soft tissue. Myeloid sarcoma may emerge as a de novo lesion or manifest as therapy related myeloid neoplasm or as disease progression within myeloproliferative neoplasm (MPN), myelodysplastic syndrome (MDS) or myelodysplastic / myeloproliferative neoplasm (MDS / MPN). In contrast, leukaemia cutis (LC) is...
Research Progress of Matrix Metalloproteinases Deriving from Parasites- Crimson Publishers Matrix metalloproteinases (MMPs) is a large family. It is named because it needs metal ions like Ca2+, Zn2+as cofactors. Its family members have similar structures and are generally composed of five domains with different functions: A. The hydrophobic signal peptide sequences; B. The prepeptide region, mainly used to maintain the stability of the zymogen. When the region is cut off by exogenous enzymes, MMPs zymogen is activated. C. The catalytic active region, having zinc ion binding sites, crucial for the enzyme catalysis. D. The hinge region rich in proline. E. The carboxyl terminal region, related to the substrate specificity of the enzyme [1]. https://crimsonpublishers.com/rmes/fulltext/RMES.000730.php For more open access journals in crimson publishers Please click on link: https://crimsonpublishers.com For more articles on Research in Medical & Engineering Sciences Pl...